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On the other hand, LC supplementation elevates fasting plasma TMAO, compound supposed to be pro-atherogenic

La evidencia sobre la L-carnitina y la prdida de grasa es, en el mejor de los casos, modesta

Within cells, L-carnitine is associated with the transport of fatty acids and has been widely studied as a nutritional compound

However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]

Cherchi A, Lai C, Angelino F, et al