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Moreover, not only the stimulation of the mesolimbic DA pathway is the critical initiating event of the neurocircuitry of AUD, but also of addiction in general [14, 28, 29] and, since our results point out that caffeine can also prevent mesolimbic DA stimulation by the receptor agonists, salsolinol and morphine, one of the future directions of this study will be to characterize further its effects on opioids-, as well as other drugs of abuse

Ferreira GC, et al

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Abstinence As we talked about earlier, the abstinence interval can affect your semen volume