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The concept of stimulating the vagus to treat disease is over a century old: as early as the late 19th century, physicians experimented with vagal stimulation for epilepsy (Badran and Austelle 2022)
even small temperature excursions accumulate across weeks of active use, and careful logging makes it straightforward to correlate experimental drift with material handling
Previous studies demonstrate that individual ligands act as allosteric modulators for multiple receptors, dramatically increasing the number of biological effects a single ligand can have (Wang et al
Pathol Oncol Res 2013
