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This can allow the discovery of MRS correlates to sensitive PET signal

255 These observations raise the prospect that these effects are mediated by receptor subtypes associated with extra-synaptic function in neuronal populations, which are also activated by low GABA concentrations and show limited desensitization 21,45,258 (see the GABA signalling within the BGM axis section)

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Doses higher than 100 mg/day are generally divided into two or three doses throughout the day (101)