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The mechanistic and animal-model data for AOD9604 are relatively mature compared with many newer peptides, given the compound's formal drug-trial history

Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)

Causes of Poor Healing: Nutrient deficiencies, compromised immune function, diabetes, and poor circulation

Thus, elimination of neighboring Cys58 by alkylation or thiolation stabilizes Cys63-SOH [178]

Cell 168 , 613628 (2017)