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Among these factors, UV radiation stands out as the most significant contributor to this form of aging
However, T2DM patients with hypertension may have higher incidence of retinal vascular leakage compared to T1DM patients, mediated by elevated endothelin-1 (ET-1) and vascular cell adhesion molecule-1 (VCAM-1) expression (84, 85)
Oncotarget (2017) 8:5782635
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