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Reason 3: The preservative stops working as designed Even if benzyl alcohol is still technically present after a freeze/thaw cycle, its antimicrobial effectiveness can degrade

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Goodyear K, Haass-Koffler CL, Chavanne D

For example, in the US NHANES 2011-2014 survey, non-hispanic black adults had higher B12 concentrations than non-hispanic white adults, even after controlling for age group and B12 supplement use (Mineva et al., 2019)