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51 Studies of dogs with osteoarthritis have shown that treatment with PEA plus quercetin, at a daily dose of 24 mg/kg body weight for four weeks, or a PEA derivative called palmitoyl-glucosamine plus curcumin for 12 months led to improvements in dog mobility and function and reductions in pain and lameness

Chin J Natural Medicines (2015) 13:83141

All of these factors matter in RA fatigue because if the gut becomes irritated by diet, stress, or other triggers, it may trigger immune activity that worsens systemic inflammation

doi: 10.3390/nu15183926 158

Acetyl-L-carnitine provides a way to carry these acetyl groups through the mitochondrial membranes back out into the cytosol