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Interestingly, cells lacking the transporter for GSH from the cytosol to the periplasm, CydDC, exhibit several phenotypes, including DTT sensitivity and swarming defects, also found in cells deficient in oxidative protein folding

In addition, it has been demonstrated that GGT-overexpressing cells were more resistant to hydrogen peroxide [67] and chemotherapics, such as doxorubicin [68], cisplatin [64], and 5-fluorouracil [69]

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[DOI] [Google Scholar] Niu S., Zhang W., Chait B