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Endothelial dysfunction is associated with decreased bioavailability of nitric oxide (NO) due to an increase in ROS, with a similar physiological change seen in cases of decreased GSH pools [16]

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Conclusion Vitamin B12 is very safe to supplement unless unusual circumstances come into play, such as an allergy, drug interaction or an excessive amount interacts poorly with an individuals body

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Al-Chalabi BM, Thanoon IA, Ahmed FA