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Glutathione is a small protein made of cysteine, glutamate (glutamic acid) and glycine

And this was in healthy young adults so you can imagine how much worse it might be in adults whose natural glutathione production is already falling

Fruit bioactive compounds: Effect on lactic acid bacteria and on intestinal microbiota

Acta Neuropathol 145: 681705, 2023

When you supplement methylfolate the body will clear a backlog of incomplete metabolic processes resulting in increased mobilisation and discharge of toxins and to avoid a healing reaction the 1 In addition to paving the way for detoxification you should use supplements to build up the other essential mineral and vitamin methyl donors (mentioned above) needed for complete methylation Sometimes its a good idea to start with phospholipids such as phosphatidylserine, phosphatidylcholine, pure choline et al, these provide a shortcut to supplying methyl groups to where they are needed compared to the long methylfolate metabolic path