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Several published observational studies suggest that PPI therapy is associated with an increased risk of osteoporosis-related fractures of the hip, wrist, and spine primarily with high-dose, prolonged use (more than 1 year)
Maurano, M
However, evidence supporting the long-term effects of intranasal GHK-Cu on cognitive performance of 5xFAD mice is limited [34, 36], emphasizing the need for additional studies
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Moreover, DHM had a minimal effect on the activity of cytochrome P450 2A5 (CYP2A5), which catalyzes NNK and NNAL bioactivation in A/J mouse lungs
