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While both the N-terminal and C-terminal regions of ATG2 exhibit affinity for membranes, studies conducted in cellular contexts suggest that the function of the N-terminal region is linked to its interaction with the ER, whereas the C-terminal amphipathic helix plays a crucial role in directing ATG2A to phagophores and lipid droplets (Tamura et al, 2017

[PubMed 8725206] 2002

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