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Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinsons Disease Model Induced by 6-OHDA

We therefore initiated treatment with BSO in the drinking water for both male and female -Myc mice at P21 and maintained it until 8 months of age, unless humane endpoints were reached

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In general, a physiologically acceptable solution will contain an effective impermeant to prevent, minimize, or reduce hypothermic induced cell swelling

This requirement for CoA could, as hypothesized, reflect a role for SNO-CoA in delivering the modifications, or it is possible that CoA binding to the E2 subunit induces a conformational change allowing the lipoic arm to be more effectively modified