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Rozen, lead author of the study

another MoA of DMF/MMF is the direct inhibition of NF-B signalling

This epigenetic silencing effectively inhibits class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, thereby reducing the production of both T-dependent and T-independent autoantibodies (e.g., anti-dsDNA antibodies)

Canonical pathways identified to be altered in TI heifers at birth and 4 months of age include epithelial adherens junction signaling (activated), atherosclerosis signaling (activated), Signaling by Rho family GTPases (activated), cardiac conduction (inhibited), and L1CAM interactions (inhibited)

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