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Due to the medicinal importance of Cordyceps spp., its popularity has increased besides the over-harvesting, triggering the scarcity of wild species

However, their therapeutic potential could be limited as a protracted use will lead to tolerance to analgesic effects requiring escalating doses that is associated with side effects such as respiratory depression

Neurons, with their high energy demands, primarily rely on oxidative phosphorylation and the tricarboxylic acid (TCA) cycle to sustain synaptic activity and neurotransmitter synthesis

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