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In addition, several agents, including CPI-613 [522], SR18292 [523] and HP661 [524], have also demonstrated the ability to target metabolic dependencies arising from mutations in mitochondrial respiratory chain subunits in studies

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Briefly, peptide antigens were synthesised and were linked to imidazoquinoline-based TLR7/8a (Barinthus Therapeutics, USA) using an azide-alkyne cycloaddition click chemistry reaction

Given these concerns, recent expert opinion advises against routine PPI co-prescription in cancer patients unless absolutely indicated and suggests considering alternative acid-suppressive strategies (e.g., H2 receptor antagonists or antacids) when required (143, 144)

Molecular hydrogen is involved in phytohormone signaling and stress responses in plants