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10.1146/annurev.me.40.020189.002211

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In the second phylogenetic group (N2, N3, N6, N7, N9), when H274Y mutation replaces residue 274 with the large-volume group tyrosine (Y), the small threonine at residue 252 means that there is enough space to accommodate the tyrosine without affecting the spatial orientation of residue 276

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