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Jeschke MG, Herndon DN, Vita R, Traber DL, Jauch KW, Barrow RE

In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

However, despite these trials, BPC-157 lacks FDA approval, raising concerns about its safety and efficacy due to insufficient clinical testing

Liu KY, Mistry RJ, Aguirre CA, Fasouli ES, Thomas MG, Klamt F, Ramsden DB, Parsons RB (2015a) Nicotinamide N -methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3

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