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Microbiota-targeted interventions, including probiotics, prebiotics, synbiotics, and dietary modulation, have demonstrated potential to improve microbial composition, alleviate systemic inflammation, enhance thyroid hormone utilization, and reduce autoantibody levels

This leads to the dissociation of TIMELESS from the replisome, slowing replication and resulting in replication stress and genome instability 17

The metabolism of GSH conjugates to mercapturic acid begins either in the biliary tree, intestine or kidney, but the formation of the N-acetylcysteine conjugate usually occurs in the kidney (DeLeve and Kaplowitz, 1990)

JX: Writing original draft, Writing review & editing