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PRRs recognize the so-called pathogen-associated molecular patterns (PAMPs) on infectious agents, which leads to internalization of the pathogen (1, 39)

Bettelheim P, Valent P, Andreeff M , Tafuri A, Haimi J, Gorischek C, Muhm M, Ch S, Haas O, Vieder L, Schulz G, Speiser W, Geissler K, Kier P, Hinterberger W, Lechner K
30 John McGrath (McClatchy News Service), Chorus of Boos Deserved for Money-Wasting Brawl, Tri-City Herald (Pasco, Washington), June 7, 1993: B2

MDD is also marked by systemic inflammation with high cytokines IL-6, TNF-, and IL-1 (Troubat et al., 2021)

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