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An Effective Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Improves Sarcopenic Obesity in Obese Mice by Modulating Skeletal Muscle Metabolism
Given the potential effects on angiogenesis and tissue growth, patients should be monitored for any signs of abnormal tissue proliferation or changes that could indicate malignant transformation
10.1038/s41401-023-01111-9 184
In addition, GPx-4 depletion in cell culture also promotes cell death by apoptotic mechanisms that could not be alleviated with water-soluble antioxidants, confirming that intracellularly GPx-4 mainly prevents lipid peroxidation, essentially antagonizing the actions of lipoxygenases and cycloogenase
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