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Description
4-HNE is a major end product of lipid peroxidation that is present in normal human plasma at concentrations ranging from 0.1M to 1.4M and this can increase more than 10 folds during oxidative stress in vivo [84]

It's a concentrated version of something your body already makes

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It gets damaged, stops functioning, or dies

Individuals with conditions that affect B12 absorption, such as pernicious anemia or gastrointestinal disorders like Crohns disease or celiac disease, can particularly benefit from B12 injections to maintain healthy red blood cell levels
