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This refers to the tingling sensation that precedes the appearance of blisters

Br J Pharmacol 2011

Antimicrobial management also includes limiting the lethal effect, especially the protection of beneficial intestinal microbiota during therapy

doi: 10.1016/S0091-6749(03)01855-4
10.1038/s41598-020-61709-5 9 CastedoM.PerfettiniJ
