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To what extent ncRNA-mediated changes in their expression influence transcription factor competition for these regulators remains to be determined

Autonomic nervous system dysfunction (ANSD) is a relevant contributor to some of the clinical features in RTT patients that leads to multiple impairments ranging from anxiety, GI dysfunction, breathing disturbances, peripheral vascular control alteration (19) to sleep issues (3), heart rate variability (HRV) (2022), and increased risk of sudden death (23, 24)

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