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In that same 1956 public address, he said, I believe that chemistry can be applied effectively to medical problems, and that through this application we may look forward to significant progress in the field of medicine as it is transformed from its present empirical form into the science of molecular medicine. In his last years at Caltech, Pauling began to research the evolutionary causes of molecular disease, arguing that the amino acid mutation that causes sickle cell anemia could be an intermediary step in evolution

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doi: 10.1007/s00280-017-3459-6 11 CapizziRLPooleMCooperMRRichardsFStuartJJJacksonDVet al