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Effect of NAC and L-NAC Pretreatment on Cellular Redox Status and PQ Uptake following PQ Challenge Exposure of cells to increasing concentrations of PQ for 24 h significantly decreased intracellular GSH content, which correlated with increases in cellular PQ uptake, as measured by UPLC (Figure 3)

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Molecular oxygen can directly destroy or cause secondary reactions that might launch oxidative activities [6]

Tafazoli and OBrien, 2009) and in vivo (Shimizu et al., 2009), the exact cellular mechanisms and pathways of AQ-QI and DEAQ-QI toxicity remain poorly understood