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These mechanisms range from molecularlevel sensitization in the periphery and central nervous system (CNS) to largescale remodeling of brain circuits, culminating in distinct clinical phenotypes classified as nociceptive, neuropathic, or nociplastic pain

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Additionally, phospholipids are metabolized by enzymes such as N -acyltransferase (NAT), diacylglycerol lipase (DAGL), and N -acylphosphatidylethanolamine phospholipase D (NAPE-PLD) into endocannabinoids 94