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This can occur due to various reasons, such as: Symptoms of a B12 deficiency can include: The frequency of B12 shots depends on the underlying cause of your B12 deficiency

Each 10 mL multi-dose vial contains 100 mcg/mL of Vitamin B12, equivalent to ten 1 mL weekly injections, making it a convenient and cost-effective option for patients requiring regular supplementation

Spoke with my doctor who assured me this is an injection-site reaction, and encouraged me to get the second shot

Draw 0.3mL per dose instead of 0.25mL to maintain 5mg dosing

A lack of vitamin B12 could lead to DNA mutations or impaired cell division