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Propionic acid is produced by gut bacteria, especially Clostridia, which produce PPA and exotoxins [100]

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However, the use of NAC for immunomodulation in HIV patients has not yet undergone prospective randomised controlled trials and therefore cannot be recommended as routine therapy in HIV infected, or other immune deficient, patients

It is notable that previous studies have suggested that the chrM:302 site serves as a rheostat for mtDNA replication versus transcription, which are functionally linked in mitochondria 3,45

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