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This begins with DNA damage, the production of ROS, subcellular organelle damage (incorporating the mitochondria and endoplasmic reticulum) and autophagy (Kim et al., 2019)

Metformin or glibenclamide combined with honey (four-week treatment) increased insulin secretion, decreased fructosamine levels and improved hyperglycemia, and reduced creatinine, bilirubin, triglycerides levels, and very low-density lipoprotein cholesterol

In: Terjung R (ed) Comprehensive physiology, 1st edn

Pantothenic acid Pantothenic acid (vitamin B 5 ) is required as a component of coenzyme A (CoA), a coenzyme needed for the oxidative metabolism of glucose and fatty acids and for the biosynthesis of fatty acids, cholesterol, steroid hormones, the hormone melatonin, and the neurotransmitter acetylcholine