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Increased knowledge of how bacteria and bacterial products such as endotoxin cross the epithelial barrier should yield data that facilitate the discovery of treatments aimed at abrogating the most feared complications of systemic endotoxemia, namely SIRS and MOF, whereas further study of paracellular permeability could likely lead to breakthroughs in the prevention of toxigenic diarrhea, a cause of substantial morbidity and mortality worldwide [87]

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Back Marks, LV (2015) The Lock and key of Medicine: Monoclonal antibodies and the transformation of healthcare

The first step, catalyzed by glutamate-cysteine ligase (GCL), is rate-limiting and regulated by GSH (competitive inhibitor) and by cysteine availability ( GSH degradation is catalized by -glutamyltranspeptidase (GGT), an enzyme that catalyzes the cleavage of the peptide bond between cysteine and the -carboxyl group of glutamate, and the transfer of the -glutamyl moiety to water (hydrolysis), an amino acid, or a short peptide (transpeptidation) (Figure 1)

4 As such, there is considerable overlap in the pathogenesis of metabolic disease, environmental toxicity, and physiologic aging