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[5] Thiamine (B) has no known major drug-drug interactions in terms of altering other medications efficacy

In a meta-analysis including data from 91 cohort or cross-sectional studies comprising more than 3.2 million patients, the prevalence of apparent and true resistant hypertension was 15% and 10% in patients treated for hypertension, respectively
Practical Applications of Computational Biology and Bioinformatics, 12th International Conference

doi: 10.1159/000284367 62 LangereisJDRaaijmakersHAUlfmanLHKoendermanL

Though there was no statistically significant difference in caregiver-rated Social Responsiveness Scale (SRS) in the group as a whole, there was statistically significant benefit in a subgroup of patients between ages 3-5