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J Physiol 236(2):303326 Costa M, Brookes SJ, Steele PA, Gibbins I, Burcher E, Kandiah CJ (1996) Neurochemical classification of myenteric neurons in the guinea-pig ileum

This may be due to limitations of the study such as enrollment of patients with many comorbidities and a high rate of patient dropout, to name but a few

doi: 10.1073/pnas.1609246113 225 WolinskyJ

You have some wiggle room, but if you fall off your schedule for too long, those signs of fatigue will inevitably return, and they almost always arrive on the scene before any other symptom does
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