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One obvious drawback of these locking solutions is that the large organic drugs cannot pass through the wall of a catheter and therefore cannot protect the exterior surface of the catheter at all although bacterial contamination may occur extraluminally due to open surgical site contamination, exit-site infection or bacteremia caused by other sources [66]

Green DR

The exact molecular structure of this pore remains obscure and its physiological functions have not been well established [183]

Lancet 351 , 726727 (1998)

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