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Inflammation likely plays a part in several of these effects, but the exact biology in humans is still not well understood

Epithalon has demonstrated a good safety profile in experimental and limited human studies, showing minimal adverse effects when used properly in research settings

Higher folate content reduction in the bread made using sourdough was explained by its acidic pH, which is less favourable for folate stability, as mentioned above 424

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However, the magnitude of 5-oxoprolinuria that occurs under these conditions is modest and overt metabolic acidosis does not develop (52,53)