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Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARgamma/OCTN2 pathway
In 2021, a single-center open-label clinical trial (N = 70 LOE2a) of LC supplementation (1000 mg/d) for 12 weeks in pediatric patients with NF showed that LC supplementation was safe and feasible, but it still needs to be confirmed in phase III clinical trials [70]
Thus, BBH.2 was confirmed in this screening as functionally active -butyrobetaine hydroxylase and used for further work on the L-carnitine biosynthetic pathway
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