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In view of the adverse effects of homocysteine on tissue integrity and its pro-oxidizing properties, organisms must rid themselves of this metabolite as quickly and as efficiently as possible
Malavolta M, Pabis K
Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart
doi: 10.1056/NEJMp1102155 43 RoqueP
The reproducibility crisis in preclinical research-lessons to learn from clinical research
