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Description
Mitochondria degradation can occur if too many toxins (also known as free radicals) build-up

Nominal voltage numbers often confuse folks and I get a fair number of related questions

Nat Rev Urol 16 , 172186 (2019)

[iv] Phenytoins zero-order (saturable) pharmacokinetics and high degree of protein binding make it challenging to achieve a consistent and therapeutic drug level in hospitals unable to measure free phenytoin levels rapidly

This is the most commonly used effective dose in clinical research
