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Over time, membrane deformability declines due to changes in lipid content and oxidative damage to proteins (61, 62)

Janosik M, Kery V, Gaustadnes M, Maclean KMN, Kraus JP: Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: Evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region

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Diagnosis and treatment usually begin after the disease shows motor symptoms

On the other hand, -syn interacts directly with mitochondrial membranes and associated proteins [114, 153, 188, 258, 259, 269], where oligomers form pore-like structures in lipid bilayers resembling the inner mitochondrial membrane (IMM), altering permeability and bioenergetics [251]