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At a stringent threshold achieving 90% precision in our test set, the variant effect map captured more than twice the number of pathogenic variants than did the best-performing computational prediction method at the same 90% precision stringency

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Various preclinical studies conducted over the past few years have found that high dosages of vitamin C could act as an adjuvant prooxidative agent, primarily in chemotherapy and/or radiotherapy of glioblastoma cells [78, 82, 84, 86]

Deficiency of GPx1 also promotes pro-inflammatory activation of endothelial and other cell types, and accelerates atherogenesis in susceptible animal models [6, 78, 79, 84, 85]

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