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S2CID 25595595

Among the various nutraceuticals under investigation, several have shown promising potential in the management of obesity and its related complications

Mechanistic investigations reveal that ERS activates the cytosolic pattern recognition receptors NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins one and 2) through bacterial peptidoglycan detection (Zangara et al., 2021), subsequently inducing inflammation and IL-6-dominated cytokine production (Keestra-Gounder et al., 2016)

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Second, after ingestion, the absorption of rotenone in the gastrointestinal tract is slow and incomplete, while it is effectively metabolized in the liver