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CLL is a heterogeneous disease, and the different subtypes of CLL have diverse metabolic requirements

While FOXO4 can influence mitochondrial function indirectly through its regulatory effects on cellular processes, it does not directly target mitochondria like the other mitochondria-targeted peptides listed above

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Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival