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References 1.Lpez-Otn C., Blasco M.A., Partridge L., Serrano M., Kroemer G

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13 Journal of Medicinal Chemistry (ACS)Bisubstrate inhibitors of NNMT with enhanced activity

However, tumor-associated blood vessels are dysfunctional and leaky (93), and the continuous exposure of BECs to pro-angiogenic factors can lead to endothelial anergy, a state in which ECs stop responding to inflammatory signals (90)

Head-to-head comparisons between arginate and acetate forms in controlled human studies would quantify the bioavailability advantage in clinical terms