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In summary, the results demonstrate that Dihexa is a metabolically stable and BBB-permeable AngIV analog that effectively reverses scopolamine-induced cognitive deficits and improves spatial learning in aged rats

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However, the most included studies did not examine the deficiency status of nutrients

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For each linear and logistic regression model, we performed sensitivity analyses by calculating E-values 70,71 , which provide estimates of the magnitude of unmeasured confounding that could explain the observed effects and have been recommended as a type of sensitivity analysis 70,72