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These mechanisms avoid the accumulation of damaged/dysfunctional proteins and of protein aggregates, which can reach a toxicity threshold when proteostasis is impaired [34, 35]
[1] [2] B12 injections are primarily prescribed for patients with pernicious anaemia , an autoimmune condition where the stomach cannot produce intrinsic factor, a protein essential for B12 absorption in the gut

International journal of physiology, pathophysiology and pharmacology , 10 (3), 132138

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A small amount of water with food is fine, but large quantities can dilute digestive enzymes and stomach acid
