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doi: 10.1016/j.redox.2025.103566 217 KwonJHLeeJKimJKirchnerVAJoYHMiuraTet al

doi: 10.1016/0300-483x(92)90142-2

[ 438 , 439 ] Sickle cell disease (SCD) is initiated as consequence of a point mutation in the globin chain of hemoglobin, which leads to a substitution of valine for glutamate at position 6, manifesting as chronic hemolytic anemia

Malondialdehyde (MDA), a terminal product of the oxidative degradation of polyunsaturated fatty acids (PUFAs), is widely used as a biomarker of lipid peroxidation (Gueraud et al., 2015)
