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After the release of NO, it immediately spreads into the cavernous body and vascular smooth muscle cells, inducing the activation of soluble guanylate cyclase and the accumulation of cyclic guanosine phosphate (cGMP), promoting the relaxation of vascular and cavernous smooth muscle by reducing intracellular Ga2+, and increasing blood flow and intracavernous pressure, resulting in penile erection (Burnett and Musicki 2005)

Moreover, both itaconate-cysteine and sulfoitaconate were found to increase dramatically by LPS stimulation in iBMDM cells, which were even more profound than the elevation of itaconate (Supplementary Fig

Ion-exchange chromatography separates proteins either on the basis of their charge type (cationic or anionic) or charge strength (e.g., strongly anionic from weakly anionic)

Jones, S.P

It is a synthetic 39-amino acid peptide that acts as an agonist at both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), producing synergistic metabolic effects that exceed those of selective GLP-1 agonists in clinical trials