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Doxorubicin toxicity to healthy cells can be reduced by targeted drug delivery as well as by reducing the administered dose

Routine screening of B12 status

Localized scalp injection increases dermal concentration at the follicle site but limits distribution to the immediate injection area practical for focal thinning but inefficient for diffuse patterns

We will get into why the injection method can be much more beneficial in a bit in this article post

The most accurate summary is that AOD-9604 has a plausible, partly-validated lipolytic mechanism in rodents and a failed pivotal efficacy trial in humans , and both facts must be held together