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Indeed, rare deactivating mutations in Akt or upstream proteins cause insulin resistance [9] and reduced activation of Akt or its upstream proteins has been observed in insulin-resistant muscle and adipose tissues of mice [10,11], rats [12] and humans [1319]

Alzheimers Dement 19:261273 [DOI] [PMC free article] [PubMed] [Google Scholar] 59.Hope Biosciences Stem Cell Research Foundation (2021) A clinical trial to determine the safety and efficacy of hope biosciences autologous mesenchymal stem cell therapy (HB-adMSCs) for the treatment of Alzheimers disease (ClinicalTrials.gov) Available at: .Accessed 12 Aug
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2.2.2.3 Reactive oxygen species homeostasis and autophagy regulation Glutamine produces reactive oxygen species (ROS) in addition to providing nitrogen and carbon for biosynthesis and energy metabolism
